Wisc. researchers unearth secrets of talin

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Using “single molecule magnetic tweezers,” the researchers measured intracellular mechanical forces (Science Advances, July 15, 2022).


They found a unique behavior of talin that shows a strong interaction and can explain the antitumor effect of DLC1 when the two proteins bind. Using the magnetic tweezers, the team tethered a protein molecule between a glass surface and a paramagnetic bead. They measured the position of the paramagnetic bead at a freely moving end of the molecule as well as the nonmagnetic bead. Both beads were glued to the same surface but opposite the protein. After applying a magnetic force and replicating the exact mechanical perturbations a protein endures, the researchers measured talin’s unfolding and refolding over the course of days.


More research on the protein interaction could be used to develop cancer drugs, the researchers concluded.


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